Total Serum IgG/IgA/IgM

GAM assesses overall production of Immunoglobulin G, Immunoglobulin A and Immunoglobulin M in the body — an important measurement of general immunity. Total immunoglobulins testing can be a strong indicator of a disease or condition.

What does measuring Total Serum IgG/IgA/IgM tell you?

Understanding the body's current state will provide direction in your treatment plan for the patient.
Deficient antibody production may be either inherited or acquired:

• Inherited immunodeficiency is associated with rare genetic conditions and serious immune disorders. However, some patients with primary IgA deficiency (IgAD) are asymptomatic and are only identified after a laboratory result anomaly.

• Acquired immunodeficiency can occur as a result of an illness, especially those that cause a loss of protein in the body such as kidney disease or gastrointestinal disorders affecting protein absorption. Recurrent infections, chronic diarrhea, and the use of certain medications such as corticosteroids or immunosuppressants may also contribute to deficient antibody production.
Excessive antibody production may be either polyclonal (increase in any or all classes of immunoglobulins) or monoclonal (increase in one class with or without a decrease in other classes).

• Polyclonal increase may occur as a result of infections, autoimmune disorders, cirrhosis of the liver, chronic inflammation, and hyperimmunization response.

• Monoclonal increase is associated with blood cell tumors such as multiple myeloma (affecting plasma cells) and lymphoma (affecting white blood cells).

Antigens Tested

  • Total Secretory IgG
  • Total Secretory IgA
  • Total Secretory IgM
CPT® Code: 83516-59 (x3)

How Does Total Serum IgG/IgA/IgM Fit in
the Cyrex System?

This panel can shed light on the potential cause of unexpected negative results on Cyrex testing by identifying whether insufficient antibody production may have contributed to those results. Additionally, acquired immunodeficiency may be reversible when the contributing condition is identified and addressed.

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Total Serum IgG/IgA/IgM (GAM).

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